Gap-AF AFNET 1 Trial


Catheter ablation of arial fibrillation by linear pulmonary vein isolation


A randomized trial to investigate the significance of complete versus incomplete electrical isolation of pulmonary veins by radiofrequency-induced linear lesions in patients with paroxysmal atrial fibrillation

Number of Patients


Coordinating Investigator

Prof. Karl-Heinz Kuck, Hamburg, Germany

Current Status



German Federal Ministry of Education and Research



Kuck KH, Hoffmann BA, Ernst S, Wegscheider K, Treszl A, Metzner A, Eckardt L, Lewalter T, Breithardt G, Willems S; Gap-AF–AFNET 1 Investigators. Impact of complete versus incomplete circumferential lines around the pulmonary veins during catheter ablation of paroxysmal atrial fibrillation: Results from the Gap-AF – AFNET 1 trialCirc Arrhythm Electrophysiol. 2016 Apr; 4: 514 - 522; 9:e003337. DOI: 10.1161/CIRCEP.115.003337 . (first published online 2016 Jan 13)

Sauer W, Callans D. The Tribulations of Atrial Fibrillation Ablation Trialists (Editorial)Circ Arrhythm Electrophysiol. 2016; 9:e003738. DOI: 10.1161/CIRCEP.115.003738