Molecular signal transduction


Molecular signal transduction pathways in atrial cardiomyocytes and their interaction with the interstitial matrix during atrial fibrillation

Coordinating Investigator

Prof. Andreas Goette, Paderborn / Magdeburg, Germany

Overall Responsibility

Atrial Fibrillation NETwork (AFNET), Münster, Germany

Current Status



German Federal Ministry of Education and Research


Goette A*, Bukowska A*, Dobrev D*, Pfeiffenberger J, Morawietz H, Strugala D, Wiswedel I, Röhl FW, Bergmann S, Bramlage P, Ravens U, Lendeckel U. Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor mediated oxidative stress and microvascular flow abnormalities in the ventricles. Eur Heart J, 05.03.2009; *shared first authorship

Bukowska A, Lendeckel U, Krohn A, Keilhoff G, ten Have S, Neumann KH, Goette A. Atrial fibrillation down-regulates renal neutral endopeptidase expression and induces profibrotic pathways in the kidney. Europace. 2008;10:1212-7.

Goette A, D'Alessandro A, Bukowska A, Kropf S, Mewis C, Stellbrink C, Tebbenjohanns J, Weiss C, Lendeckel U. Rationale for and design of the CREATIVE-AF trial: randomized, double-blind, placebo-controlled, crossover study of the effect of irbesartan on oxidative stress and adhesion molecules in patients with persistent atrial fibrillation. Clin Drug Investig. 2008; 28:565-72.

Hammwöhner M, Smid J, Lendeckel U, Goette A. New drugs for atrial fibrillation. J Interv Card Electrophysiol. 2008; 23:15-21. Review.

Bukowska A, Schild L, Keilhoff G, Hirte D, Neumann M, Gardemann A, Neumann KH, Röhl FW, Huth C, Goette A, Lendeckel U. Mitochondrial dysfunction and redox signaling in atrial tachyarrhythmia. Exp Biol Med (Maywood). 2008; 233:558-74.

Goette A, Lendeckel U. Electrophysiological effects of angiotensin II. Part I: signal transduction and basic electrophysiological mechanisms. Europace. 2008; 10:238-41. Review.

Goette A, Bukowska A, Lendeckel U, Erxleben M, Hammwöhner M, Strugala D, Pfeiffenberger J, Röhl FW, Huth C, Ebert MP, Klein HU, Röcken C. Angiotensin II receptor blockade reduces tachycardia-induced atrial adhesion molecule expression. Circulation. 2008; 117(6):732-42.

Bukowska A, Lendeckel U, Hirte D, Wolke C, Striggow F, Röhnert P, Huth C,. Klein HU, Goette A. (2006) Activation of the Calcineurin Signaling Pathway Induces Atrial Hypertrophy During Atrial Fibrillation. J Cell Mol Life Sci; 63: 333-342.