Molecular causes


Molecular and electrophysiological causes of atrial fibrillation in a transgenic model (CREM-IbDC-X-transgenic mouse)

Coordinating Investigator

Prof. Paulus Kirchhof, Birminham, UK

Overall Responsibility

Atrial Fibrillation NETwork (AFNET), Münster, Germany

Current Status



German Federal Ministry of Education and Research


Kirchhof P, Marijon E, Fabritz L, Li N, Wang W, Wang T, Schulte K, Hanstein J, Schulte JS, Vogel M, Mougenot N, Laakmann S, Fortmueller L, Eckstein J, Verheule S, Kaese S, Staab A, Grote-Wessels S, Schotten U, Moubarak G, Wehrens XH, Schmitz W, Hatem S, Müller FU. Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice. Int J Cardiol. 2011; 166; 366–74. DOI:10.1016/j.ijcard.2011.10.057.