RE-LATED AF – AFNET 7

Title

Resolution of Left Atrial-Appendage Thrombus – Effects of Dabigatran in patients with Atrial Fibrillation (RE-LATED AF)

Summary

RE-LATED AF is a prospective, multicenter, randomized, open-label, controlled, explorative, blinded-endpoint (PROBE) trial to compare the efficacy of Dabigatran (150 mg bid) with Phenprocoumon for the resolution of left atrial appendage thrombus formation in patients with atrial fibrillation. RE-LATED AF is an investigator initiated trial (IIT).

Current Status

Patient enrolment ended prematurely
60 patients enrolled
Status as of 22.05.2019

Planned Number of Patients

110

Participating Countries

Germany (15 study centers)

Coordinating Investigator

Univ.-Prof. Dr. Thomas Rostock, Mainz

Overall Responsibility

Sponsor: Universitätsmedizin der Johannes Gutenberg-Universität Mainz

Partners

Scientific Partners
Kompetenznetz Vorhofflimmern e.V., Münster, Germany

Interdisziplinäres Zentrum Klinische Studien (IZKS), Universitätsmedizin Mainz, Germany

 

Publications

Ferner M, Wachtlin D, Konrad T, Deuster O, Meinertz T, von Bardeleben S, Münzel T, Seibert-Grafe M, Breithardt G, Rostock T. Rationale and design of the RE-LATED AF-AFNET 7 trial: REsolution of Left atrial-Appendage Thrombus-Effects of Dabigatran in patients with Atrial Fibrillation. Clin Res Cardiol. 2016; 105:29-36. doi:10.1007/s00392-015-0883-7. Epub 2015 Jun 25.

Financial Supporter       
The trial is partially supported by Boehringer Ingelheim Pharma GmbH & Co. KG.

Registration

EudraCT: 2013-005364-26
ClinicalTrials.gov NCT02256683

Contacts

Univ.-Prof. Dr. Thomas Rostock
Universitätsmedizin Mainz
II. Medizinische Klinik und Poliklinik
Abteilung für Elektrophysiologie
Langenbeckstraße 1
D-55131 Mainz, Germany
Phone: +49 6131 173696
Fax: +49 6131 175534
Email: thomas.rostock[at]unimedizin-mainz.de

Interdisziplinäres Zentrum Klinische Studien (IZKS)
c/o Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Langenbeckstraße 2
D-55131 Mainz, Germany
Phone: +49 6131 179913
Fax: +49 6131 179914
Email: izks[at]izks-mainz.de
http://www.izks-mainz.de