Resolution of Left Atrial-Appendage Thrombus – Effects of Dabigatran in patients with Atrial Fibrillation (RE-LATED AF)


RE-LATED AF is a prospective, multicenter, randomized, open-label, controlled, explorative, blinded-endpoint (PROBE) trial to compare the efficacy of Dabigatran (150 mg bid) with Phenprocoumon for the resolution of left atrial appendage thrombus formation in patients with atrial fibrillation. RE-LATED AF is an investigator initiated trial (IIT).

Current Status

Patient enrolment is ongoing since July 2014
60 patients enrolled
Status as of 30.06.2017, updates are carried out quarterly

Planned Number of Patients


Participating Countries

Germany (15 study centers)

Coordinating Investigator

Univ.-Prof. Dr. Thomas Rostock, Mainz

Overall Responsibility

Sponsor: Universitätsmedizin der Johannes Gutenberg-Universität Mainz


Scientific Partners
Kompetenznetz Vorhofflimmern e.V., Münster, Germany

Interdisziplinäres Zentrum Klinische Studien (IZKS), Universitätsmedizin Mainz, Germany



Ferner M, Wachtlin D, Konrad T, Deuster O, Meinertz T, von Bardeleben S, Münzel T, Seibert-Grafe M, Breithardt G, Rostock T. Rationale and design of the RE-LATED AF-AFNET 7 trial: REsolution of Left atrial-Appendage Thrombus-Effects of Dabigatran in patients with Atrial Fibrillation. Clin Res Cardiol. 2016; 105:29-36. doi:10.1007/s00392-015-0883-7. Epub 2015 Jun 25.

Financial Supporter       
The trial is partially supported by Boehringer Ingelheim Pharma GmbH & Co. KG.


EudraCT: 2013-005364-26 NCT02256683


Kompetenznetz Vorhofflimmern e.V.
Mendelstraße 11
48149 Münster, Germany
Phone: +49 251 980 1330
Fax: +49 251 980 1349
Email: info[at]

Univ.-Prof. Dr. Thomas Rostock
Universitätsmedizin Mainz
II. Medizinische Klinik und Poliklinik
Abteilung für Elektrophysiologie
Langenbeckstraße 1
D-55131 Mainz, Germany
Phone: +49 6131 173696
Fax: +49 6131 175534
Email: thomas.rostock[at]

Interdisziplinäres Zentrum Klinische Studien (IZKS)
c/o Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Langenbeckstraße 2
D-55131 Mainz, Germany
Phone: +49 6131 179913
Fax: +49 6131 179914
Email: izks[at]