Non-vitamin K antagonist Oral anticoagulants in patients with Atrial High rate episodes

This study is partially funded by the German Centre for Cardiovascular Research (DZHK).

Current Status
1618 patientes enrolled
179 sites open for recruitment
Status as of 2nd July 2020, updates are carried out quarterly

Planned Number of Patients

Participating Countries

17 European countries: Austria, Belgium, Bulgaria, Czech Republic, France, Germany, Great Britain, Greece, Hungary, Italy, Netherlands, Poland, Portugal, Romania, Sweden, Spain, Ukraine

International Chief Investigator

Prof. Paulus Kirchhof, Birmingham, UK / Münster, Germany

Overall Responsibility

Sponsor: Kompetenznetz Vorhofflimmern e.V.  (AFNET e.V.), Münster, Germany 

Flyer for investigators


Bertaglia E, Blank B, Blomstrom-Lundqvist C, Brandes A, Cabanelas N, Dan GA, Dichtl W, Goette A, deGroot JR, Lubinski A, Marijon E, Merkely B, Mont L, Piorkowski C, Sarkozy A, Sulke N, Vardas P, Velchev V, Wichterle D, and Kirchhof P. Atrial high-rate episodes: prevalence, stroke risk, implications for management, and clinical gaps in evidence. Europace. 2019; 0, 1–9. doi:10.1093/europace/euz172

Camm AJ, Simantirakis E, Goette A, Lip GY, Vardas P, Calvert M, Chlouverakis G, Diener HC, Kirchhof P. Atrial high-rate episodes and stroke prevention. Europace. 2017 Feb 1;19(2):169-179. doi: 10.1093/europace/euw279. Epub 2016 Feb 29.

Kirchhof P, Blank BF, Calvert M, Camm AJ, Chlouverakis G, Diener HC, Goette A, Huening A, Lip GYH, Simantirakis E, Vardas P. Probing oral anticoagulation in patients with atrial high rate episodes: Rationale and design of the Non-vitamin K antagonist Oral anticoagulants in patients with Atrial High rate episodes (NOAH-AFNET 6) trial. Am Heart J. 2017 Aug;190:12-18. doi: 10.1016/j.ahj.2017.04.015. Epub 2017 May 3.

Registration NCT02618577

ISRCTN 17309850

EudraCT number: 2015-003997-33