Early treatment of atrial fibrillation for stroke prevention trial (EAST)

This study is partially funded by the DZHK 


The EAST trial is to test whether an early, comprehensive, rhythm control therapy can prevent adverse cardiovascular outcomes in patients with atrial fibrillation (AF) compared to usual care.
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Current Status

Patient enrolment ended on 31.12.2016
2.789 patients randomized
94 sites were open for recruitment
Status as of 31.12.2016, updates are carried out quarterly

Number of Patients


Participating Countries

Belgium, Czech Republic, Denmark, France, Germany, Great Britain, Italy, Poland, Spain, Switzerland, The Netherlands

Coordinating Investigators

Prof. Paulus Kirchhof, Birmingham, UK / Münster, Germany
Prof. Günter Breithardt, Münster, Germany
Prof. Harry Crijns, Maastricht, NL
Prof. John Camm, London, UK

Overall Responsibility

Sponsor: Kompetenznetz Vorhofflimmern e.V.  (AFNET e.V.), Münster, Germany


Scientific Partner:

European Heart Rhythm Association (EHRA)


Deutsches Zentrum für Herz-Kreislauf-Forschung e.V. (DZHK)

Financial Supporters:

Sanofi, Paris, France

St. Jude Medical, St. Paul, Minn., USA

Deutsche Herzstiftung e.V. (German Heart Foundation)


Haegeli L, Aliot E, Brandes A, Eckardt L, Elvan A, Gulizia M, Heidbuchel H, Kautzner J, Mont L, Morgan J, Ng A, Szumowski L, Themistoclakis S, Van Gelder IC, Willems S, Kirchhof P. The EAST study: redefining the role of rhythmcontrol therapy in atrial fibrillation: EAST, the Early treatment of Atrial fibrillation for Stroke prevention Trial. Eur Heart J. 2015 Feb 1;36(5):255-6. doi: 10.1093/eurheartj/ehu476.

Kirchhof P, Breithardt G, Camm AJ, Crijns H, Kuck K-H, Vardas P, Wegscheider K. Improving outcomes in patients with atrial fibrillation: Rationale and design of the Early treatment of Atrial fibrillation for Stroke prevention Trial. Am Heart J 2013; 166(3):442-8. doi:10.1016/j.ahj.2013.05.015

Van Gelder IC, Haegeli LM, Brandes A, Heidbuchel H, Aliot E, Kautzner J, Szumowski L, Mont L, Morgan J, Willems S, Themistoclakis S, Gulizia M, Elvan A, Smit MD, Kirchhof P. Rationale and current perspective for early rhythm control therapy in atrial fibrillation. Europace 2011;13:1517-25. DOI:10.1093/europace/eur192.

Flyer for investigators


ClinicalTrials.gov:  NCT01288352
EudraCT number: 2010-021258-20


Kompetenznetz Vorhofflimmern e.V.
Mendelstraße 11
48149 Münster, Germany
Phone: +49 251 980 1330
Fax: +49 251 980 1349
Email: info@kompetenznetz-vorhofflimmern.de