EAST – AFNET 4

Title

Early treatment of atrial fibrillation for stroke prevention trial (EAST)

This study is partially funded by the DZHK 

Summary

The EAST trial is to test whether an early, comprehensive, rhythm control therapy can prevent adverse cardiovascular outcomes in patients with atrial fibrillation (AF) compared to usual care.
read more

Current Status

End of Patient enrolment: 31st December 2016
Follow-Up ongoing
2.789 patients randomized
94 sites open for recruitment
Satus as of December 2018

Planned Number of Patients

2.745

Participating Countries

Belgium, Czech Republic, Denmark, France, Germany, Great Britain, Italy, Poland, Spain, Switzerland, The Netherlands

Coordinating Investigators

Prof. Paulus Kirchhof, Birmingham, UK / Münster, Germany
Prof. Günter Breithardt, Münster, Germany
Prof. Harry Crijns, Maastricht, NL
Prof. John Camm, London, UK

Overall Responsibility

Sponsor: Kompetenznetz Vorhofflimmern e.V.  (AFNET e.V.), Münster, Germany

Partners

Scientific Partner:

European Heart Rhythm Association (EHRA)

 

Deutsches Zentrum für Herz-Kreislauf-Forschung e.V. (DZHK)

Financial Supporters:

Sanofi, Paris, France

St. Jude Medical, St. Paul, Minn., USA

Deutsche Herzstiftung e.V. (German Heart Foundation)

Publications

Haegeli L, Aliot E, Brandes A, Eckardt L, Elvan A, Gulizia M, Heidbuchel H, Kautzner J, Mont L, Morgan J, Ng A, Szumowski L, Themistoclakis S, Van Gelder IC, Willems S, Kirchhof P. The EAST study: redefining the role of rhythmcontrol therapy in atrial fibrillation: EAST, the Early treatment of Atrial fibrillation for Stroke prevention Trial. Eur Heart J. 2015 Feb 1;36(5):255-6. doi: 10.1093/eurheartj/ehu476. Epub 2015 Jan 30.

Kirchhof P, Breithardt G, Camm AJ, Crijns H, Kuck K-H, Vardas P, Wegscheider K. Improving outcomes in patients with atrial fibrillation: Rationale and design of the Early treatment of Atrial fibrillation for Stroke prevention Trial. Am Heart J 2013; 166(3):442-8. doi:10.1016/j.ahj.2013.05.015

Van Gelder IC, Haegeli LM, Brandes A, Heidbuchel H, Aliot E, Kautzner J, Szumowski L, Mont L, Morgan J, Willems S, Themistoclakis S, Gulizia M, Elvan A, Smit MD, Kirchhof P. Rationale and current perspective for early rhythm control therapy in atrial fibrillation. Europace 2011;13:1517-25. DOI:10.1093/europace/eur192.

Flyer for investigators

Registration

ClinicalTrials.gov:  NCT01288352
http://clinicaltrials.gov/ct2/show/NCT01288352?term=NCT01288352&rank=1
ISRCTN:  ISRCTN04708680
http://www.controlled-trials.com/ISRCTN04708680
EudraCT number: 2010-021258-20
Website
http://www.easttrial.org

Contact

Kompetenznetz Vorhofflimmern e.V.
Mendelstraße 11
48149 Münster, Germany
Phone: +49 251 980 1330
Fax: +49 251 980 1349
Email: info[at]kompetenznetz-vorhofflimmern.de
http://www.kompetenznetz-vorhofflimmern.de