Anticoagulation using the direct factor Xa inhibitor apixaban during Atrial Fibrillation catheter Ablation: Comparison to vitamin K antagonist therapy (AXAFA)

This study is partially funded by the DZHK


AXAFA – AFNET 5 is an investigator-driven, prospective, parallel-group, randomised, open, blinded outcome assessment (PROBE), multi-centre trial to determine the optimal anticoagulation therapy for patients undergoing catheter ablation of atrial fibrillation.
Read more

Current Status

Patient enrolment has endend on 10.04.2017
674 patientes enrolled
49 sites were open for recruitment
Status as of 29.06.2017

Planned Number of Patients


Participating Countries

Europe, USA

International Chief Investigator

Prof. Paulus Kirchhof, Birmingham, UK / Münster, Germany

Overall Responsibility

Sponsor: Kompetenznetz Vorhofflimmern e.V.  (AFNET e.V.), Münster, Germany  



Deutsches Zentrum für Herz-Kreislauf-Forschung e.V. (DZHK)

Financial Supporters:

Bristol-Myers Squibb


Flyer for investigators


Kirchhof P, Haeusler KG, Blank B, De Bono J, Callans D, Elvan A, Fetsch T, Van Gelder IC, Gentlesk P, Grimaldi M, Hansen J, Hindricks G, Al-Khalidi HR, Massaro T, Mont L, Nielsen JC, Nölker G, Piccini JP, De Potter T, Scherr D, Schotten U, Themistoclakis S, Todd D, Vijgen J, Di Biase L. Apixaban in patients at risk of stroke undergoing atrial fibrillation ablation. Eur Heart J. 2018 Aug 21; 00:1-14. doi: 10.1093/eurheartj/ehy176. Epub 2018 Mar 20.

Di Biase L, Callans D, Georg Haeusler K, Hindricks G, Al-Khalidi H, Mont L, Cosedis Nielsen J, Piccini JP, Schotten U, Kirchhof P. Rationale and design of AXAFA-AFNET 5: an investigator-initiated, randomized, open, blinded outcome assessment, multi-centre trial to comparing continuous apixaban to vitamin K antagonists in patients undergoing atrial fibrillation catheter ablation. Europace. 2017 Jan;19(1):132-138. doi: 10.1093/europace/euw368. Epub 2016 Oct 14.


EudraCT number: 2014-002442-45 NCT02227550


Kompetenznetz Vorhofflimmern e.V.
Mendelstraße 11
48149 Münster, Germany
Phone: +49 251 980 1330
Fax: +49 251 980 1349 
Email: info[at]