Contractile Remodeling in Atrial Fibrillation


Contractile remodeling in atrial fibrillation: Mechanisms and therapeutic approaches

Coordinating Investigator

Prof. Ulrich Schotten, Maastricht

Overall Responsibility

Kompetenznetz Vorhofflimmern - Competence Network on Atrial Fibrillation


German Federal Ministry of Education and Research


Schotten U, Verheule S, Kirchhof P, Goette A. Pathophysiological mechanisms of atrial fibrillation: a translational appraisal. Physiol Rev. 2011;91:265-325. Review. Erratum in: Physiol Rev. 2011;91:1533. DOI:10.1152/physrev.00031.2009

Greiser M, Neuberger HR, Harks E, El-Armouche A, Boknik P, de Haan S, Verheyen F, Verheule S, Schmitz W, Ravens U, Nattel S, Allessie MA, Dobrev D, Schotten U. Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation. J Mol Cell Cardiol. 2009; 46(3):385-94.

Greiser M, Halaszovich CR, Frechen D, Boknik P, Ravens U, Dobrev D, Lückhoff A, Schotten U: Pharmacological evidence for altered src-kinase regulation of ICa,L in patients with chronic atrial fibrillation., Naunyn Schmiedeberg’s Arch Pharmacol, 2007 375(6):383-92.

Schotten U, de Haan S, Verheule S, Harks E, Frechen D, Bodewig E, Greiser M, Ram R, Maessen J, Kelm M, Allessie M, Van Wagoner D.: Blockade of atrial-specific K-currents increases atrial but not ventricular contractility by enhancing reverse mode Na/Ca-exchange., Cardiovasc Res 2007;73:37-47

de Haan S, Greiser M, Harks E, Blaauw Y, van Hunnik A, Verheule S, Allessie M, Schotten U: AVE0118, Blocker of the Transient Outward Current (Ito) and Ultrarapid Delayed Rectifier Current (IKur), Fully Restores Atrial Contractility After Cardioversion of Atrial Fibrillation in the Goat.; Circulation 2006;114:1234-42

Goette A, Schotten U. Inhibition of angiotensin II type 1 receptors reduces atrial stunning and spontaneous echo contrast after electrical cardioversion of atrial fibrillation. Eur Heart J. 2006; 27(17): 2034-2035.

Kirchhof P, Schotten U.: Hypertension begets hypertrophy begets atrial fibrillation? Insights from yet another sheep model.; Eur Heart J. 2006 Dec;27:2919-20.

Ravens U, Wettwer E, Schotten U, Weßel R, Dobrev D: Neue Antiahythmika in der Therapie des Vorhofflimmerns II. Ionenkanalblocker; Herzschr Elektrophys 2006, 17: 64-72.

Schotten U, Dobrev D, Kirchhof P, Kääb S, Lewalter T, Goette A: Pathophysiologie des Vorhofflimmerns; Deutsches Ärzteblatt. 2006; 103 (25):B1491-B1497.

Schotten U, Dobrev D, Kirchhof P, Kääb S, Lewalter T, Goette A: Vorhofflimmern: Grundlagenforschung bietet neue Chancen für innovative pharmakologische Therapieansätze.; Deutsches Ärzteblatt 2006, 103(25): A1743-A1748. (Joint activity of several Section C network members)