Veröffentlichungen aus dem Kompetenznetz Vorhofflimmern

AFNET-Publikationen 2009

Benjamin EJ, Rice KM, Arking DE, Pfeufer A, van Noord C, Smith AV, Schnabel RB, Bis JC, Boerwinkle E, Sinner MF, Dehghan A, Lubitz SA, D'Agostino RB Sr, Lumley T, Ehret GB, Heeringa J, Aspelund T, Newton-Cheh C, Larson MG, Marciante KD, Soliman EZ, Rivadeneira F, Wang TJ, Eiríksdottir G, Levy D, Psaty BM, Li M, Chamberlain AM, Hofman A, Vasan RS, Harris TB, Rotter JI, Kao WH, Agarwal SK, Stricker BH, Wang K, Launer LJ, Smith NL, Chakravarti A, Uitterlinden AG, Wolf PA, Sotoodehnia N, Köttgen A, van Duijn CM, Meitinger T, Mueller M, Perz S, Steinbeck G, Wichmann HE, Lunetta KL, Heckbert SR, Gudnason V, Alonso A, Kääb S, Ellinor PT, Witteman JC. Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat Genet. 2009; 41(8):879-81.

Chelu MG, Sarma S, Sood S, Wang S, van Oort RJ, Skapura DG, Li N, Santonastasi M, Müller FU, Schmitz W, Schotten U, Anderson ME, Valderrábano M, Dobrev D, Wehrens XH. Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest. 2009;119(7):1940-51.

Dobrev D, Teos LY, Lederer WJ. Unique atrial myocyte Ca2+ signaling. J Mol Cell Cardiol. 2009; 46(4):448-51.

Gemein C, Schauerte P, Hatam N, Rana OR, Saygili E, Meyer C, Eickholt C, Schmid M, Knackstedt C, Zarse M, Mischke K. Targeting of cardiac autonomic plexus for modulation of intracardiac neural tone. Europace. 2009; 11(8):1090-6.

Gerth A, Nabauer M, Limbourg T, Oeff M, Ravens U, Meinertz T, Breithardt G, Steinbeck G. Gender-specific differences in symptom burden and management of atrial fibrillation in the AFNET: Data from a large prospective clinical registry. Eur Heart J 2009; 30 (Abstract Suppl): 818

Girmatsion Z, Biliczki P, Bonauer A, Wimmer-Greinecker G, Scherer M, Moritz A, Bukowska A, Goette A, Nattel S, Hohnloser SH, Ehrlich JR. Changes in microRNA-1 expression and IK1 up-regulation in human atrial fibrillation. Heart Rhythm. 2009; 6(12):1802-9.

Goette A*, Bukowska A*, Dobrev D*, Pfeiffenberger J, Morawietz H, Strugala D, Wiswedel I, Röhl FW, Bergmann S, Bramlage P, Ravens U, Lendeckel U. Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor mediated oxidative stress and microvascular flow abnormalities in the ventricles. Eur Heart J, 05.03.2009; *shared first authorship

Greiser M, Neuberger HR, Harks E, El-Armouche A, Boknik P, de Haan S, Verheyen F, Verheule S, Schmitz W, Ravens U, Nattel S, Allessie MA, Dobrev D, Schotten U. Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation. J Mol Cell Cardiol. 2009; 46(3):385-94.

Hinterseer M, Beckmann BM, Thomsen MB, Pfeufer A, Dalla Pozza R, Loeff M, Netz H, Steinbeck G, Vos MA, Kääb S. Relation of increased short-term variability of QT interval to congenital long-QT syndrome. Am J Cardiol. 2009; 103(9):1244-8.

Kääb S, Darbar D, van Noord C, Dupuis J, Pfeufer A, Newton-Cheh C, Schnabel R, Makino S, Sinner MF, Kannankeril PJ, Beckmann BM, Choudry S, Donahue BS, Heeringa J, Perz S, Lunetta KL, Larson MG, Levy D, MacRae CA, Ruskin JN, Wacker A, Schömig A, Wichmann HE, Steinbeck G, Meitinger T, Uitterlinden AG, Witteman JC, Roden DM, Benjamin EJ, Ellinor PT. Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation. Eur Heart J. 2009; 30(7):813-9.

Kirchhof P, Bax J, Blomstrom-Lundquist C, Calkins H, Camm AJ, Cappato R, Cosio F, Crijns H, Diener HC, Goette A, Israel CW, Kuck KH, Lip G, Nattel S, Page R, Ravens U, Schotten U, Steinbeck G, Vardas P, Waldo A, Wegscheider K, Willems S, Breithardt G. Early and comprehensive management of AF: Proceedings from the 2nd AFNET-EHRA consensus conference on atrial fibrillation entitled “research perspectives in AF”. Europace 2009; 11(7):860-85.

Kirchhof P, Bax J, Blomstrom-Lundquist C, Calkins H, Camm AJ, Cappato R, Cosio F, Crijns H, Diener HC, Goette A, Israel CW, Kuck KH, Lip G, Nattel S, Page R, Ravens U, Schotten U, Steinbeck G, Vardas P, Waldo A, Wegscheider K, Willems S, Breithardt G. Early and comprehensive management of AF: Exectuvie summary of the proceedings from the 2nd AFNET-EHRA consensus conference “research perspectives in AF”. Eur Heart J 2009; 30(24):2969-77c.

Nabauer M, Gerth A, Limbourg T, Schneider S, Oeff M, Kirchhof P, Goette A, Lewalter T, Ravens U, Meinertz T, Breithardt G, Steinbeck G. The Registry of the German Competence NETwork on Atrial Fibrillation: patient characteristics and initial management. Europace. 2009; 11:423-34.

Pfeufer A, Sanna S, Arking DE, Müller M, Gateva V, Fuchsberger C, Ehret GB, Orrú M, Pattaro C, Köttgen A, Perz S, Usala G, Barbalic M, Li M, Pütz B, Scuteri A, Prineas RJ, Sinner MF, Gieger C, Najjar SS, Kao WH, Mühleisen TW, Dei M, Happle C, Möhlenkamp S, Crisponi L, Erbel R, Jöckel KH, Naitza S, Steinbeck G, Marroni F, Hicks AA, Lakatta E, Müller-Myhsok B, Pramstaller PP, Wichmann HE, Schlessinger D, Boerwinkle E, Meitinger T, Uda M, Coresh J, Kääb S, Abecasis GR, Chakravarti A. Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat Genet. 2009; 41(4):407-14.

Saygili E, Rana OR, Meyer C, Gemein C, Andrzejewski MG, Ludwig A, Weber C, Schotten U, Krüttgen A, Weis J, Schwinger RH, Mischke K, Rassaf T, Kelm M, Schauerte P. The angiotensin-calcineurin-NFAT pathway mediates stretch-induced up-regulation of matrix metalloproteinases-2/-9 in atrial myocytes. Basic Res Cardiol. 2009; 104(4):435-48.

Zellerhoff S, Pistulli R, Mönnig G, Hinterseer M, Beckmann BM, Köbe J, Steinbeck G, Kääb S, Haverkamp W, Fabritz L, Gradaus R, Breithardt G, Schulze-Bahr E, Böcker D, Kirchhof P. Atrial Arrhythmias in long-QT syndrome under daily life conditions: a nested case control study. J Cardiovasc Electrophysiol. 2009; 20(4):401-7.

AFNET-Publikationen 2008

Andrié R, Goette A, Lewalter T. Verhinderung von Vorhofflimmern: Rhythmuskontrolle. Klinikarzt 2008; 37 (2): 73-79

Breithardt G, Dobrev D, Doll N, Goette A, Hoffmann B, Kirchhof P, Köster I, Kuck KH, Leute A, Meinertz T, Näbauer M, Oeff M, Ravens U, Schuchert A, Sprenger C, Steinbeck G, Willems S. The German Competence Network on Atrial Fibrillation (AFNET). Herz. 2008 Dec;33(8):548-555.

Breithardt G. Vorhofflimmern – wenn das Herz aus dem Takt gerät. Klinikarzt 2008; 37 (2): 64

Bukowska A, Lendeckel U, Krohn A, Keilhoff G, ten Have S, Neumann KH, Goette A. Atrial fibrillation down-regulates renal neutral endopeptidase expression and induces profibrotic pathways in the kidney. Europace. 2008 Oct;10(10):1212-7. Epub 2008 Aug 8.

Bukowska A, Schild L, Keilhoff G, Hirte D, Neumann M, Gardemann A, Neumann KH, Röhl FW, Huth C, Goette A, Lendeckel U. Mitochondrial dysfunction and redox signaling in atrial tachyarrhythmia. Exp Biol Med (Maywood). 2008 May;233(5):558-74.

Christ T, Wettwer E, Voigt N, Hála O, Radicke S, Matschke K, Várro A, Dobrev D, Ravens U. Pathology-specific effects of the IKur/Ito/IK,ACh blocker AVE0118 on ion channels in human chronic atrial fibrillation. Br J Pharmacol. 2008 Aug;154(8):1619-30.

Dobrev D, Nattel S. Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeutics. J Cardiovasc Pharmacol. 2008 Oct;52(4):293-9.

Dobrev D, Teos LY, Lederer WJ. Unique atrial myocyte Ca(2+) signaling. J Mol Cell Cardiol. 2008 Dec 25. [Epub ahead of print]

Dobrev D, Wettwer E. Four and a half LIM protein 1: a novel chaperone for atrium-specific Kv1.5 channels with a potential role in atrial arrhythmogenesis. Cardiovasc Res. 2008 Jun 1;78(3):411-2.

Dobrev D. New concepts in understanding and modulating atrial repolarisation in patients with atrial fibrillation. J Interv Card Electrophysiol. 2008 Aug;22(2):107-10. Epub 2008 Mar 11. Review.

Drewitz I, Rostock T, Hoffmann B, Steven D, Servatius H, Meinertz T, Willems S. Aktuelle Therapiestrategien bei Vorhofflimmern; unter Mitarbeit des Kompetenznetzes Vorhofflimmern (AFNET). [In Process Citation] Med Klin (Munich). 2008 Nov 15;103(11):788-800.

Eckstein J, Verheule S, de Groot N, Allessie M, Schotten U. Mechanisms of perpetuation of atrial fibrillation in chronically dilated atria. Prog Biophys Mol Biol. 2008 Jun-Jul;97(2-3):435-51. Review.

El-Armouche A, Wittköpper K, Degenhardt F, Weinberger F, Didié M, Melnychenko I, Grimm M, Peeck M, Zimmermann WH, Unsöld B, Hasenfuss G, Dobrev D, Eschenhagen T.  Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy. Cardiovasc Res. 2008 Dec 1;80(3):396-406.

Goette A, Braun-Dullaeus RC. Atrial fibrillation is associated with impaired cognitive function and hippocampal atrophy: silent cerebral ischaemia vs. Alzheimer's disease? Eur Heart J. 2008 Aug 1. [Epub ahead of print]

Goette A, Bukowska A, Lendeckel U, Erxleben M, Hammwöhner M, Strugala D, Pfeiffenberger J, Röhl FW, Huth C, Ebert MP, Klein HU, Röcken C. Angiotensin II receptor blockade reduces tachycardia-induced atrial adhesion molecule expression. Circulation. 2008 Feb 12;117(6):732-42.

Goette A, D'Alessandro A, Bukowska A, Kropf S, Mewis C, Stellbrink C, Tebbenjohanns J, Weiss C, Lendeckel U.  Rationale for and design of the CREATIVE-AF trial: randomized, double-blind, placebo-controlled, crossover study of the effect of irbesartan on oxidative stress and adhesion molecules in patients with persistent atrial fibrillation. Clin Drug Investig. 2008;28(9):565-72.

Goette A, Lendeckel U. Electrophysiological effects of angiotensin II. Part I: signal transduction and basic electrophysiological mechanisms. Europace. 2008 Feb;10(2):238-41. Review.

Greiser M, Neuberger HR, Harks E, El-Armouche A, Boknik P, de Haan S, Verheyen F, Verheule S, Schmitz W, Ravens U, Nattel S, Allessie MA, Dobrev D, Schotten U. Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation. J Mol Cell Cardiol. 2008 Nov 27. [Epub ahead of print]

Kirchhof P, Breithardt G. Vorhofflimmern – eine Standortbestimmung: Vorkommen, Mechanismen und klinische Präsentation. Klinikarzt 2008; 37 (2): 66-70

Knackstedt C, Gramley F, Schimpf T, Mischke K, Zarse M, Plisiene J, Schmid M, Lorenzen J, Frechen D, Neef P, Hanrath P, Kelm M, Schauerte P.  Association of echocardiographic atrial size and atrial fibrosis in a sequential model of congestive heart failure and atrial fibrillation. Cardiovasc Pathol. 2008 Sep-Oct;17(5):318-24.

Knackstedt C, Schauerte P, Kirchhof P. Electro-anatomic mapping systems in arrhythmias. Europace. 2008 Nov;10 Suppl 3:iii28-34.

Knecht S, Oelschläger C, Duning T, Lohmann H, Albers J, Stehling C, Heindel W, Breithardt G, Berger K, Ringelstein EB, Kirchhof P, Wersching H. Atrial fibrillation in stroke-free patients is associated with memory impairment and hippocampal atrophy. Eur Heart J. 2008 Jul 29. [Epub ahead of print]

Knecht S, Wersching H, Lohmann H, Bruchmann M, Duning T, Dziewas R, Berger K, Ringelstein EB. High-normal blood pressure is associated with poor cognitive performance. Hypertension. 2008 Mar;51(3):663-8.

Koebe J, Kirchhof P. Novel non-pharmacological approaches for antiarrhythmic therapy of atrial fibrillation. Europace. 2008 Apr;10(4):433-7. Review.

Leute A, Breithardt G. Volkskrankheit Vorhofflimmern. Forum Sanitas 2008; 3: 3-5

Leute A, Doll N, Goette A, Kääb S, Kirchhof P, Kuck KH, Meinertz T, Näbauer M, Oeff M, Ravens U, Schuchert A, Steinbeck G, Willems S, Weiß T, Breithardt G. Klinische Studien und Register im Kompetenznetz Vorhofflimmern. DZKF 2008; 12: 71-78

Lutomsky B, Willems S, Meinertz T. Prävention von Schlaganfällen bei Vorhofflimmern: Antithrombotische Therapie. Klinikarzt 2008; 37 (2): 89-94

Meinertz T, Willems S. Treatment of atrial fibrillation in every days practice. Internist (Berl). 2008 Dec;49(12):1437-42, 1444-5.

Nattel S, Burstein B, Dobrev D. Atrial remodelling and atrial fibrillation: mechanisms and implications. Circ Arrhythmia Electrophysiol. 2008; 1: 62-73.

Plisiene J, Blumberg A, Haager G, Knackstedt C, Latsch J, Norra C, Arndt M, Tuerk S, Heussen N, Kelm M, Predel HG, Schauerte P. Moderate physical exercise: a simplified approach for ventricular rate control in older patients with atrial fibrillation. Clin Res Cardiol. 2008 Nov;97(11):820-6.

Qi XY, Yeh YH, Xiao L, Burstein B, Maguy A, Chartier D, Villeneuve LR, Brundel BJJM, Dobrev D, Nattel N. Cellular signaling underlying atrial tachycardia remodeling of L-type calcium current. Circ Res. 2008; 103(8): 845-854.

Schauerte P, Näbauer M, Steinbeck G. Einstellung der Kammerfrequenz bei persistierendem und permanentem Vorhofflimmern: Frequenzkontrolle. Klinikarzt 2008; 37 (2): 81-86

Schuchert A, Wegscheider K, Meinertz T. Stellenwert präventiver Vorhofstimulation zur Reduktion von paroxysmalem Vorhofflimmern bei Schrittmacherpatienten (BACEPACE-Studie). Effect of preventive atrial pacing on the reduction of paroxysmal atrial fibrillation in pacemaker patients (BACEPACE study). Kardiologe 2008; 2(6): 500-505

Sinner MF, Pfeufer A, Akyol M, Beckmann BM, Hinterseer M, Wacker A, Perz S, Sauter W, Illig T, Näbauer M, Schmitt C, Wichmann HE, Schömig A, Steinbeck G, Meitinger T, Kääb S. The non-synonymous coding IKr-channel variant KCNH2-K897T is associated with atrial fibrillation: results from a systematic candidate gene-based analysis of KCNH2 (HERG). Eur Heart J. 2008 Apr;29(7):907-14.

Sood S, Chelu M, Van Oort R, Skapura D, Santonastasi M, Dobrev D, Wehrens XHT. Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation. Heart Rhythm 2008; 5(7): 1047-54.

Sprenger C, Oeff M, Tebbe U, Breithardt G, Meinertz T, Ravens U, Steinbeck G, Häusler KG. Zerebrovaskuläre Komplikationen bei Vorhofflimmern - Zwischenanalyse des prospektiven Registers des Kompetenznetz Vorhofflimmern. Clin Res Cardiol Suppl. 2008; 97: V337

Voigt N, Maguy A, Yeh YH, Qi X, Ravens U, Dobrev D, Nattel S. Changes in IK,ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes. Cardiovasc Res. 2008; 77: 35-43.

Yeh Y-H, Wakili R, Qi X, Chartier D, Boknik P, Kääb S, Ravens U, Coutu P, Dobrev D, Nattel S. Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure. Circ Arrhythmia Electrophysiol. 2008; 1: 93-102.

AFNET-Publikationen 2007

Breithardt G, Leute A: The German Competence Network on Atrial Fibrillation – From Basic Research to Patient Care”; Hjerteforum (Journal of the Norwegian Cardiac Society), Jun. 2007

Breithardt G: Editorial „Das Kompetenznetz Vorhofflimmern schreitet fort – aktuelle Berichte“; Die Medizinische Welt, April 2007

Cosio F, Aliot E, Botto G, Heidbüchel H, Geller J, Kirchhof P, J-C DH, Frank R, Villacastin J, Vijgen J, Crijns H: Delayed rhythm control of atrial fibrillation may be a cause of failure to prevent recurrences - reasons for change to active antiarrhythmic treatment at the time of the first detected episode; Europace 2007-08

Dobrev D, Christ T, Boknik P, Wöhrl S, Bosch RF, Ravens U: Regulation of left atrial L-type Ca2+ channels in patients with chronic atrial fibrillation; J Mol Cell Cardiol, 42 (Suppl. 1): S20 (doi:10.1016/j.yjmcc.2007.03.057)

Dobrev D: 5-Hydroxytryptamine and atrial arrhythmogenesis: a “culprit mechanism” or a bystander in patients with chronic atrial fibrillation, J Mol Cell Cardiol 2007, 42: 51-3

Doll N, Czesla M, Borger M, Merk D, Mohr FW; Die chirurgische Behandlung des Vorhofflimmerns- Surgical treatment of atrial fibrillation; Die Medizinische Welt, April 2007

Drewitz I, Ernst S, Kuck K-H, Breithardt G, Lutomsky B, Willems S: Katheterablation von Vorhofflimmern – Pulmonary vein ablation – the GAP-AF trial“ : Die Medizinische Welt, April 2007

El-Armouche A, Pohlmann L, Schlossarek S, Starbatty J, Yeh YH, Nattel S, Dobrev D, Eschenhagen T, Carrier L: Decreased phosphorylation levels of cardiac myosin binding protein-C in human and experimental heart failure; J Mol Cell Cardiol 2007; 43:223-229

Fabritz L, Breithardt G, Kirchhof P.: Preclinical Testing of Drug-Induced Proarrhythmia: Value of Transgenic Models; Cardiovasc Hematol Agents Med Chem. 2007 Oct; 5(4):289-294

Goette A, Breithardt G, Fetsch T, Hanrath P, Klein HK, Lehmacher 5, Steinbeck G, Meinertz T.: Angiotensin II-Antagonist inParoxysmal Atrial Fibrillation (ANTIPAF)-Trial: rationale and study design; Clin Drug Invest 2007; 27(10):697-705

Goette A, Bukowska A, Lendeckel U: Non-ionchannel blockers as antiarrhythmic drugs (reversal of structural remodelling: Curr Opin Pharmacol 2007;7:219-224

Goette A, D’Alessandro A, Meinertz T: Die ANTIPAF Studie. Aktivierung des Renin-Angiotensin-Systems - ein neuer Faktor für das Entstehen von Vorhofflimmern?; Med Welt 2007; 58:138-140

Goette A, Lendeckel U, Klein HU.: Elektrophysiologie und Pathophysiologie von Vorhofflimmern.; In: Vorhofflimmern Vorhofflattern (Neuzner J & Pitschner HF, Eds.). pp 39-73, Steinkopff Verlag Darmstadt, 2007

Goette A, Lendeckel U, Kuchenbecker A, Bukowska A, Peters B, Klein H, Huth C, Röcken C.: Cigarette smoking induces via nicotine a proarrhythmic atrial fibrosis in humans., Heart. 2007 Sep;93(9):1056-63. Epub 2007 Mar 29. PMID: 17395670

Greiser M, Halaszovich CR, Frechen D, Boknik P, Ravens U, Dobrev D, Lückhoff A, Schotten U: Pharmacological evidence for altered src-kinase regulation of ICa,L in patients with chronic atrial fibrillation., Naunyn Schmiedeberg’s Arch Pharmacol, 2007 375(6):383-92.

Hammwöhner M, D'Alessandro A, Wolfram O, Goette A: New pharmacologic approaches to prevent thromboembolism in patients with atrial fibrillation; Curr Vasc Pharmacol. 2007 Jul;5(3):211-9.

Hammwöhner M, Ittenson A, Dierkes J, Bukowska A, Lendeckel U, Klein H, Goette A:, Increased expression of CD40/CD40L and adhesion molecules during AF, Exp Biol Med 2007;232(4):581-589.

Hammwöhner M, Ittenson A, Dierkes J, Bukowska A, Peters B, Klein H, Lendeckel U, Goette A.: Platelet Expression of CD40/CD40 Ligand And its Relation to Inflammatory Markers and Adhesion Molecules in Patients with Atrial Fibrillation., Exp Biol Med, 2007, 232(4):581-9,
Kääb S, Schotten U, Dobrev D, Kirchhof P, Ravens U, Götte A: Grundlagenforschung ist eine Voraussetzung für innovative pharmakologische Therapieansätze bei Vorhofflimmern.; MedWelt 2007; 58: 131-134.

Kirchhof P, Andresen D,. Meinertz T,. Steinbeck G,. Weiss T,. Breithardt G; „Gezielte pharmakologische Umkehr des elektrischen Remodelling durch Kurzzeit-Antiarrhythmika-Therapie? – Targeted phermacological reversal of electrical remodelling by short-term antiarrhythmic drug treatment after cardioversion. The Flec-SL study within AFNET“ ; Die Medizinische Welt, April 2007

Kirchhof P, Auricchio A, Bax J, Crijns H, Camm J, Diener HC, et al: Outcome parameters for trials in atrial fibrillation: Recommendations from a consensus conference organized by the German Atrial Fibrillation Competence NETwork and the European Heart Rhythm Association. ; Europace. 2007 Sep 25:published on line Sept 25, 2007,

Kirchhof P, Auricchio A, Bax J, Crijns H, Camm J, Diener HC, Goette A, Hindricks G, Hohnloser S, Kappenberger L, Kuck KH, Lip GY, Olsson B, Meinertz T, Priori S, Ravens U, Steinbeck G, Svernhage E, Tijssen J, Vincent A, Breithardt G:  Outcome parameters for trials in atrial fibrillation: executive summary: Recommendations from a consensus conference organized by the German Atrial Fibrillation Competence NETwork (AFNET) and the European Heart Rhythm Association (EHRA).; Eur Heart J 2007:published online Sept 25, 2007

Kirchhof P, Breithardt G:  Behandlung von Vorhofflimmern, Internist (Berl). 2007 Aug;48:819-31.

Kirchhof P, Breithardt G: New concepts for old drugs to maintain sinus rhythm in patients with atrial fibrillation.; Heart Rhythm 2007;Juni 4 (6): 790-3

Kirchhof P, Goette A, Hindricks G, Hohnloser S, Kuck KH, Meinertz T, Ravens U, Steinbeck G, Breithardt G. Endpunkte für Studien bei Patienten mit Vorhofflimmern - Bericht über ein Konsensus-Papier von AFNET und EHRA. Herzschrittmacherther Elektrophysiol. 2007 Dec;18(4):259-68.

Kirchhof P, Klimas J, Fabritz L, Zwiener M, Jones LR, Schafers M, et al.: Stress and high heart rate provoke ventricular tachycardia in mice expressing triadin.; J Mol Cell Cardiol. 2007 May;42:962-71.

Kirchhof P: New antiarrhythmic drugs and new concepts for old drugs.; Journal of Interventional Cardiac Electrophysiologie 2007

Kirchhof P; Fortmueller L, Waldeyer C, Breithardt G, Fabritz L: Drugs that interact with cardiac electro-mechanics: Old and new targets for treatment; Progr Biophys Mol Biol (2007/2008) in press

Leute A: AFNET/EHRA Consensus Conference on Endpoints for Atrial Fibrillation Trials”; EHRA Newsletter 3/2007

Näbauer M: Viele Alte mit hohem Risiko sind nicht antikoaguliert; Cardio News 2007; 06:10, 29

Roell W, Lewalter T, Sasse P, Tallin Y, Choi BR, Breitbach M, Doran R, Becher U, Hwang S-M, Bostani T, von Maltzahn J, Hofmann A, Reining S, Doering B, Gabris B, Pfeifer A, Welz A, Willecke K, Salama G, Schrickel J, Kotlikoff M, Fleischmann B: Engraftment of connexin43-expressing cells prevents post-infarct arrythmia; Nature 2007

Schotten U, de Haan S, Verheule S, Harks E, Frechen D, Bodewig E, Greiser M, Ram R, Maessen J, Kelm M, Allessie M, Van Wagoner D.: Blockade of atrial-specific K-currents increases atrial but not ventricular contractility by enhancing reverse mode Na/Ca-exchange., Cardiovasc Res 2007;73:37-47

Schrickel JW, Brixius K, Herr C, Clemen C, Sasse P, Reetz K, Grohé C, Meyer R, Tiemann K, Schröder R, Bloch W, Nickening G, Fleischmann B, Noegel A, Schwinger R, Lewalter T: Enhanced heterogeneity of myocardial conduction and severe cardiac electrical instability in annexin A7-deficient mice, Cardiovasc Res 2007; 257-268

Voigt N, Christ T, Wettwer E, Bock M, Knaut M, Strasser RH, Ravens U, Dobrev D: Differential phosphorylation-dependent regulation of constitutively active and muscarinic-receptor activated IK,ACh channels in patients with chronic atrial fibrillation, Cardiovasc Res. 2007 74(3):426-43

Voigt N, Maguy A, Yeh YH, Qi X, Ravens U, Dobrev D, Nattel S.: Changes in lK, ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes; Cardiovasc Res. 2007 Oct 26; [Epub ahead of print]

Wetter E, Christ T, Dobrev D, Ravens U: Novel antiarrhythmic agents for treatment of atrial fibrillation, Curr Opin Pharmacol 2007, 7(2): 214-218

AFNET-Publikationen 2006

Arking DE, Pfeufer A, Post W, Kao WH, Newton-Cheh C, Ikeda M, West K, Kashuk C, Akyol M, Perz S, Jalilzadeh S, Illig T, Gieger C, Guo CY, Larson MG, Wichmann HE, Marban E, O'donnell CJ, Hirschhorn JN, Kääb S, Spooner PM, Meitinger T, Chakravarti A.: A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization; Nat Genet. 2006;38(6):644-651

Barth AS, Kääb S: MAPK= mitogen-activated protein KChIP2? Unraveling signaling pathways controlling cardiac Ito expression.; Circ Res. 2006; 98(3):301-2

Barth AS, Kuner R, Buness A, Ruschhaupt M, Merk S, Zwermann L, Kaab S, Kreuzer E, Steinbeck G, Mansmann U, Poustka A, Nabauer M, Sultmann H: Identification of a common gene expression signature in dilated cardiomyopathy across independent microarray studies; J Am Coll Cardiol. 2006;48(8):1610-7. Epub 2006 Sep 27.

Dagres N, Kottkamp H, Piorkowski C, Doll N, Mohr F, Horlitz M, Kremastinos DT, Hindricks G: Rapid detection and successful treatment of esophageal perforation after radiofrequency ablation of atrial fibrillation: lessons from five cases.; J Cardiovasc Electro-physiol. 2006 Nov;-17(11):1213-5. Epub 2006 Sep 20. PMID: 16987382 [PubMed - indexed for MEDLINE]

de Haan S, Greiser M, Harks E, Blaauw Y, van Hunnik A, Verheule S, Allessie M, Schotten U: AVE0118, Blocker of the Transient Outward Current (Ito) and Ultrarapid Delayed Rectifier Current (IKur), Fully Restores Atrial Contractility After Cardioversion of Atrial Fibrillation in the Goat.; Circulation 2006;114:1234-42

Dobrev D, Ravens U: Do genetics help to better understand the underlying mechanisms of atrial fibrillation? ; Eur Heart J 2006; 27(14): 1640-1641

Dobrev D: Electrical remodeling in atrial fibrillation.; Herz Cardiovascular Diseases 2006, 31(2): 108-112

Doll N, Mohr FW: Vorhofflimmern: chirurgische Verfahren; In Broschüre Herzrhythmusstörungen heute. Deutsche Herzstiftung Juli 2006.

El-Armouche A, Bednorz A, Pamminger T, Ditz D, Didie M, Dobrev D, Eschenhagen T: Role of calcineurin and protein phosphatase-2A in regulation of phosphatase inhibitor-1 in cardiac myocytes.; Biochem Biophys Res Commun 2006; 346(3): 700-6

El-Armouche A, Boknik P, Eschenhagen T, Carrier L, Knaut M, Ravens U, Dobrev D; Molecular determinants of altered Ca2+-handling in human chronic atrial fibrillation.; Circulation 2006; 114; 670-680

Goette A: Innovative therapeutic approach to atrial fibrillation: AT1-receptor blocker.; Dtsch Med Wochenschr. 2006;131 (34-35 Suppl 4): S103-107.

Hammwöhner M, D`Alessandro A, Dobrev D, Kirchhof P, Goette A: Neue Antiarrhythmika in der Therapie des Vorhofflimmerns II. Nicht-Ionenkanalblocker.; Herzschr Elektrophys 2006, 17: 73-80. (Joint activity of projects C1, C4 and C6)

Hammwöhner M, D’Alessandro A, Dobrev D, Kirchhof P, Goette A: Neue Antiarrhythmika in der Therapie des Vorhofflimmerns II. Nicht-Ionenkanalblocker.; Herzschr Elektrophys 2006; 17: 73-80.

Kääb S: Tuning the Beat: Differential Expression of Ion Channels in the Sinus Node: Circ. Res. 2006; 99; 1283-1284

Kirchhof P, Schotten U.: Hypertension begets hypertrophy begets atrial fibrillation? Insights from yet another sheep model.; Eur Heart J. 2006 Dec;27:2919-20.

Knackstedt C, Franke A, Mischke K, Zarse M, Gramley F, Schimpf T, Plisiene J, Muehlenbruch G, Spuentrup E, Ernst S, Willems S, Kirchhof P, Schauerte P.; Semi- automated 3-dimensional intracardiac echocardiography: Development and initial clinical experience of a new system to guide ablation procedures.; Heart Rhythm. 2006;3:1453-9

Leute A, Kirchhof P, Breithardt G, Goette A, Lewalter T, Meinertz T, Oeff M, Ravens U, Steinbeck G, Weiss T.  [German Competence Network on Atrial Fibrillation (AFNET): A nationwide cooperation for better research and patient care; Med Klin 2006; 15;101(8):662-6.

Ravens U, Dobrev D, Götte A: Neue Aspekte in der Therapie des Vorhofflimmerns.; Herzschr Elektrophys 2006; 17: 61-63

Ravens U, Wettwer E, Schotten U, Weßel R, Dobrev D: Neue Antiahythmika in der Therapie des Vorhofflimmerns II. Ionenkanalblocker; Herzschr Elektrophys 2006, 17: 64-72.

Schotten U, Dobrev D, Kirchhof P, Kääb S, Lewalter T, Goette A: Pathophysiologie des Vorhofflimmerns; Deutsches Ärzteblatt. 2006; 103 (25):B1491-B1497.

Schotten U, Dobrev D, Kirchhof P, Kääb S, Lewalter T, Goette A: Vorhofflimmern: Grundlagenforschung bietet neue Chancen für innovative pharmakologische Therapieansätze.; Deutsches Ärzteblatt 2006, 103(25): A1743-A1748. (Joint activity of several Section C network members)

Schotten U, Dobrev D, Kirchhof P, Kääb S, Lewalter T,Goette A: Optimising the management of atrial fibrillation – insights from a national expert network.; Deutsches Ärzteblatt 2006;103:A1743-1748

Suwalski P, Suwalski G, Doll N, Majstrak F, Kurowski A, Suwalski KB: Epicardial beating heart "off-pump" ablation of atrial fibrillation in non-mitral valve patients using new irrigated bipolar radiofrequency technology.; Ann Thorac Surg. 2006 Nov;82(5):1876-9. PMID: 17062264 [PubMed - indexed for MEDLINE

Zellerhoff S, Goette A, Kirchhof P: Antikoagulation bei Vorhofflimmern.; Herzschr Elektrophys. 2006; 17: 89-94

AFNET-Publikationen 2005

Barth AS, Merk S, Arnoldi E, Zwermann L, Kloos P, Gebauer M, Steinmeyer K, Bleich M, Kääb S, Pfeufer A, Überfuhr P, Dugas M, Steinbeck G, Näbauer M: Functional profiling of human atrial and ventricular gene expression: Pflugers Arch-Eur J Physiol. 2005; 450: 201-8

Breithardt G: "Das Kompetenznetz Vorhofflimmern"; Medizinische Welt, Sep. 2005
Duning T, Kloska S, Steinsträter O, Kugel H, Heindel W, Knecht S: Dehydration confounds the assessment of brain atrophy; NEUROLOGY 2005; 64: 548-50

Ellinghaus P, Scheubel RJ, Dobrev D, Ravens U, Holtz J, Huetter J, Nielsch U, Morawietz H: Comparing the Global mRNA Expression Profile of Human Atrial and Ventricular Myocardium with High-Density Oligonucleotide Arrays; J Thorac Cardiovasc Surg 2005; 129: 1383-90

Gaborit N, Steenman M, Lamirault G, Le Meur N, Le Bouter S, Lande G, Léger J, Charpentier F, Christ T, Dobrev D, Escande D, Nattel S, Demolombe S: Human Atrial Ion Channel and Transporter Subunit Gene-Expression Remodeling Associated With Valvular Heart Disease and Atrial Fibrillation; Circulation 2005; 112: 471-81

Goette A, Oeff M: Pathophysiologie des Vorhofflimmerns: Therapie der Grundkrankheit; Med Welt 2005; 56: 366-9

Goette A: Aktivierung des Renin-Angiotensin-Systems: Ein neuer Faktor für das Entstehen oder Aufrechterhaltung des Vorhofflimmerns? Die ANTIPAF Studie; Cardio News 3, 2005 ; Seite 49

Goette A: Neue Strategien zur Behandlung von Vorhofflimmern: Beispiel für die gezielte Überprüfung basiswissenschaftlicher Resultate in klinischen Studien.; Newsletter of the BMBF: June 2005

Kääb S, Schulze-Bahr E: Susceptibility genes and modifiers for cardiac arrhythmias; Cardiovascular Research 2005; 67: 397-413

Kirchhof P, Engelen M, Franz MR, Ribbing M, Wasmer K, Breithardt G, Haverkamp W, Eckardt L: Electrophysiological effects of flecainide and sotalol in the human atrium during persistent atrial fibrillation; Basic Res Cardiol 2005; 100: 12-20

Kirchhof P, Fabritz L, Franz MR: Recording monophasic action potentials. In: Dhein S, Mohr FW, Delmar M, editors.; Methods in Cardiovascular Research, New York: Futura; 2005. p. 417-31

Kirchhof P, Fetsch T, Hanrath, P, Meinertz T, Steinbeck G, Lehmacher W, Breithardt G: Targeted Pharmacological Reversal of Electrical Remodeling after Cardioversion - Rationale and Design of the Flec-SL Trial; Am Heart J 2005; 150:899, 899

Kirchhof P, Mönnig G, Wasmer K, Heinecke A, Breithardt G, Eckardt L, Böcker D: A trial of self-adhesive patch electrodes and hand-held paddle electrodes for external cardioversion of atrial fibrillation (MOBIPAPA); Eur Heart J. 2005 Jul;26(13):1292-7. Epub 2005 Feb 25.

Kirchhof P: Cardiovert! - or better wait a little? First systematic evidence that the initial hours of atrial fibrillation are a "special time"; Heart Rhythm. 2005 Dec;2(12):1330-1.

Lendeckel U, Müller C, Röcken C, Laube B, Täger M, Huth C, Klein HU, Goette A: Expression of opioid receptor subtypes and their ligands in fibrillating human atria; PACE 2005; 28 (Suppl.1) S1-S5

Lewalter T, Doll N, Ernst S, Kuck KH, Lutomsky B, Lüderitz B, Mohr FW, Schuchert A, Willems S: Nicht-medikamentöse Therapie des Vorhofflimmerns; Med Welt 2005; 56: 378-85

Nieuwlaat R, Capucci A, Camm AJ, Olsson SB, Andresen D, Davies DW, Cobbe S, Breithardt G, Le Heuzey JY, Prins MH, Lévy S, Crijns HJGM: Atrial fibrillation management: a prospective survey in ESC Member Countries. The Euro Heart Survey on Atrial Fibrillation; European Heart Journal Advance Access published October 4, 2005

Pfeufer A, Jalilzadeh S, Perz S, Mueller JC, Hinterseer M, Illig T, Akyol M, Huth C, Schopfer-Wendels A, Kuch B, Steinbeck G, Holle R, Näbauer M, Wichmann HE, Meitinger T, Kääb S: Common Variants in Myocardial Ion Channel Genes Modify the QT-Interval in the General Population. Results From the KORA Study; Circ Res. 2005; 96: 693-701

Schauerte P, Kirchhof P: Medikamentöse Therapie von Vorhofflimmern; Med Welt 2005; 56: 370-5

Vest JA, Wehrens XHT, Reiken SR, Lehnart SE, Dobrev D, Chandra P,  Danilo P, Ravens U, Rosen MR, Marks AR: Defective Cardiac Ryanodine Receptor Regulation During Atrial Fibrillation: Circulation 2005; 111: 2025-32

AFNET-Publikationen 2004

Bukowska A, Lendeckel U, Kähne T, Goette A: Proteomics in myocardial diseases; Pathology Research and Practice 2004; 200: 135-45

Christ T, Boknik P, Wöhrl S, Wettwer E, Graf EM, Bosch RF, Knaut M, Schmitz W, Ravens U, Dobrev D: L-type Ca2+ Current Downregulation in Chronic Human Atrial Fibrillation Is Associated with Increased Activity of Protein Phosphatases; Circulation 2004; 110: 2651-7

Christ T, Rauwolf T, Braun M, Dobrev D, Ravens U, Strasser RH: Recording atrial monophasic action potentials using standard leads: an alternative way to study electrophysiological properties of the human atrium in vivo?; PACE 2004; 27: 1632-7

Dobrev D, Christ T, Ravens U: Muscarinic subtype-2 receptor autoantibodies: actors or bystanders in human atrial fibrillation?; European Heart Journal 2004; 25: 1091-2

Dobrev D: Molekulare Grundlagen des Remodeling bei Vorhofflimmern; Dtsch Med Wochenschr 2004; 129; 827-30

Goette A, Lendeckel U: Nonchannel drug targets in atrial fibrillation; Pharmacology and Therapeutics 2004; 102: 17-36

Goette A, Lendeckel U: Tachycardia-induced remodeling: atria and ventricles take a different route; Cardiovascular Research 2004; 63: 194-5

Goette A, Röcken C: Atrial amyloidosis and atrial fibrillation: a gender-dependent "arrhythmogenic substrate"?; European Heart Journal 2004; 25, 1185-1186

Goette A, Weber M, Lendeckel U, Welte T, Lutze G, Klein HU: Effect of physical exercise on platelet activity and the von-Willebrand-factor in patients with persistent lone atrial fibrillation; ournal of Interventional Cardiac Electrophysiology 2004; 10: 139-146

Goette A: Die ANTIPAF Studie; Newsletter of the German Network of Competence in Atrial Fibrillation: No 3 . November 2004

Knecht S, Berger K: Einfluss vaskulärer Faktoren auf die Entwicklung einer Demenz; Deutsches Ärzteblatt 2004; 101: 31–32:A2185-2189

Wettwer E, Hála O, Christ C, Heubach JF, Dobrev D, Knaut M, Varró A, Ravens U: Role of IKur in Controlling Action Potential Shape and Contractility in the Human Atrium - Influence of Chronic Atrial Fibrillation; Circulation 2004; 110: 2299-2306

AFNET-Publikationen 2003

Goette A, Lendeckel U: New insights into molecular mechanisms of atrial fibrillation: Are we approaching possible novel pharmacological principals for treating this disorder?; Heart Drug 2003; 3(4): 180-190

Goette A., Jentsch-Ullrich K, Lendeckel U, Röcken C, Agbaria M, Auricchio A, Mohren M, Franke A, Klein, HU: Effect of Atrial Fibrillation on Hematopoietic Progenitor Cells. A novel pathophysiological role of the atrial natriuretic peptide?; Circulation 2003; 108: 2446-9

Kirchhof P, Eckardt L, Franz MR, Mönnig G, Loh P, Wedekind H, Schulze-Bahr Breithardt G, Haverkamp W: Prolonged Atrial Action Potential Durations and Polymorphic Atrial Tachyarrhythmias in Patients with Long QT Syndrome; J Cardiovasc Electrophysiol 2003; 14: 1027-33

Kirchhof P, Schulze-Bahr E: Atrial fibrillation, thromboembolism, and haemostasis: causal or casual associations?; Thromb Haemost 2003; 90: 973-5 (editorial comment)