AXAFA – AFNET 5

Title

Anticoagulation using the direct factor Xa inhibitor apixaban during Atrial Fibrillation catheter Ablation: Comparison to vitamin K antagonist therapy (AXAFA)

This study is partially funded by the DZHK
 

Summary

AXAFA – AFNET 5 is an investigator-driven, prospective, parallel-group, randomised, open, blinded outcome assessment (PROBE), multi-centre trial to determine the optimal anticoagulation therapy for patients undergoing catheter ablation of atrial fibrillation.
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Current Status

Patient enrolment has endend on 10.04.2017
674 patientes enrolled
49 sites were open for recruitment
Status as of 29.06.2017

Number of Patients

630

Participating Countries

Europe, USA

International Chief Investigator

Prof. Paulus Kirchhof, Birmingham, UK / Münster, Germany

Overall Responsibility

Sponsor: Kompetenznetz Vorhofflimmern e.V.  (AFNET e.V.), Münster, Germany  

Partners

 

Deutsches Zentrum für Herz-Kreislauf-Forschung e.V. (DZHK)

Financial Supporters:

Bristol-Myers Squibb

Pfizer

Flyer for investigators

Publications

Kirchhof P, Haeusler KG, Blank B, De Bono J, Callans D, Elvan A, Fetsch T, Van Gelder IC, Gentlesk P, Grimaldi M, Hansen J, Hindricks G, Al-Khalidi HR, Massaro T, Mont L, Nielsen JC, Nölker G, Piccini JP, De Potter T, Scherr D, Schotten U, Themistoclakis S, Todd D, Vijgen J, Di Biase L. Apixaban in patients at risk of stroke undergoing atrial fibrillation ablation. Eur Heart J. 2018; 00, 1-14. doi: 10.1093/eurheartj/ehy176

Di Biase L, Callans D, Georg Haeusler K, Hindricks G, Al-Khalidi H, Mont L, Cosedis Nielsen J, Piccini JP, Schotten U, Kirchhof P. Rationale and design of AXAFA-AFNET 5: an investigator-initiated, randomized, open, blinded outcome assessment, multi-centre trial to comparing continuous apixaban to vitamin K antagonists in patients undergoing atrial fibrillation catheter ablation. Europace. 2017 Jan;19(1):132-138. doi: 10.1093/europace/euw368

Registration

EudraCT number: 2014-002442-45
ClinicalTrials.gov: NCT02227550
ISRCTN: ISRCTN87711003

Contact

Kompetenznetz Vorhofflimmern e.V.
Mendelstraße 11
48149 Münster, Germany
Phone: +49 251 9801340
Fax: +49 251 9801349 
Email: info@kompetenznetz-vorhofflimmern.de
http://www.kompetenznetz-vorhofflimmern.de